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WHAT IS MELATONIN?Melatonin is a neurohormone secreted by the pineal gland (a pea-size structure at the centre of the brain) when our eyes detect the fall of darkness. The level of melatonin in our bodies increases at night, and helps our bodies to regulate our sleep-wake cycles. The amount of melatonin produced by the body lessens as we get older. Scientists believe this is why young people have less trouble sleeping than older people. Melatonin is a safe, effective sleep aid that has no danger of addiction or the harmful side effects of prescription drugs. Melatonin also eases jet-lag and may have other uses. It has been reported to improve mood, strengthen the immune system, and reduce free radicals in the body. Current research is underway to determine Melatonin's uses;- as an anti-oxidant, as an Imuno-modulator in cancer, in delayed sleep-phase disorders, and in jet-lag. Research has suggested that Melatonin may regulate the entire ageing process.
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WHY TAKE MELATONIN? Studies suggest that low-dose supplements can hasten sleep and ease jet-lag, without the hazards or unpleasant side effects of prescription sleeping pills.
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WHAT IS THE RECOMMENDED DOSAGE?The appropriate dose can vary enormously from person to person, and successful results have been achieved with dosages ranging from .1mg (100mcg ) to 200mg (200,000mcg). Start off with a low dosage each night (e.g. 300mcg) and increase the dosage if required. You should normally wake up refreshed and full of energy. If you wake up feeling a little tired you should reduce your dose until you wake up feeling well refreshed. You should not have the hang-over effect you may experience with over-the-counter or prescription sleeping drugs. In fact some sleeping drugs can actually reduce the levels of Melatonin that the body produces, making you more dependent on their use, and upsetting your natural sleep-cycle even more.
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IS MELATONIN SAFE?Melatonin is one of the least toxic substances known. In the most extensive clinical trial to date a high dose of 75mg of Melatonin per day was given to 1400 women in the Netherlands for up to four years with no ill effects. The FDA reports that in the four years that Melatonin has been available for sale over-the-counter in the United States, no alarming side effects have been reported. According to one report, "10 percent of the users said the hormone did nothing for them, and another 10 percent complained of side effects such as nightmares, headaches, morning grogginess, mild depression, and low sex drive. In past studies researchers have given people up to 600 to 3,000 times the usual doses, without causing any toxicity".
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SHOULD CERTAIN PEOPLE AVOID TAKING MELATONIN?Yes. "Those include women who are pregnant or nursing (since no-one yet knows how excessive exposure to the hormone might affect a fetus or infant); people with severe allergies or auto immune diseases (Melatonin could exacerbate such conditions by stimulating the immune system); people with immune system cancers, such as lymphoma or leukemia (for the same reason), and healthy children (who already produce it in abundance). Women trying to conceive should also think twice before taking it as high doses can act as a contraceptive". People with diabetes or depression should consult their doctors before taking it. As with any substance introduced into your body, if you have any medical condition or are already taking medication, you should consult your physician before taking Melatonin.
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CAN I BE SURE OF THE PURITY?The Melatonin we supply is of the highest quality and purity available. It has been approved by the F.D.A. and independently analysed to be more than 99% pure. Unlike some other manufacturers products, our Melatonin is NOT bovine-derived and is of the highest pharmaceutical grade. It is not mixed with vitamins or other active ingredients and it is suitable for vegetarians.
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WHAT IS "PHARMACY GRADE" MELATONIN?'Natural', 'Animal' or 'Bovine Grade' Melatonin contains the actual extracts of the pineal gland. Because it comes from animal tissue, this grade of Melatonin may be accompanied by viruses or proteins that could cause an antibody response. We highly recommend that people keep away from it, particularly in the light of the recent scares about the possible transmission of diseases from cattle to humans. The alternative is 'Synthetic' or 'Pharmacy Grade' Melatonin which is produced from pharmaceutical grade ingredients. This form is molecularly identical to the Melatonin that we produce in our own bodies, without unwanted extras, and is the only type we supply.
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SOME EXTRACTS FROM PERIODICALS ON MELATONIN;Melatonin useful in insomnia management..."Melatonin is a sleep-inducing neurohormone that shows promise as an occasional hypnotic for insomnia, jet-lag and to readjust the sleep patterns in shift workers", "especially in patients older than 40 years. "Because Melatonin levels decrease with age, it's very likely that an older person will have a Melatonin deficiency". (Source - Dr R.Sahelian. Reported by Reuters Medical News.)
SAD (Seasonal Affective Disorder)...Winter depression is believed to be caused by the decreased amount of sunlight during shorter winter days. Sunlight striking the retina has been linked to the production of Melatonin, which in turn can effect mood. (Source - Reuters Medical News.)
Sleep disorders are more common in the blind...The high frequency of sleep/wake disorders is an additional handicap to these individuals. A study on the effects of the light-sensitive hormone Melatonin upon the sleep cycle is planned. (Source - The Lancet.)
Magnetic Fields Increase Breast Cancer..."The mechanism proposed is that increasing exposure to magnetic fields decreases production by the pineal gland of Melatonin, a hormone that inhibits mammary carcinogenesis". "Blood levels of Melatonin are lower in rats with breast cancer". (Source - Reuters.)
Insomniacs swear by Melatonin..."Researchers have shown that Melatonin, a hormone produced in the brain, plays a role in regulating the sleep wake cycle in humans. "Levels of Melatonin fluctuate with time of day -- about ten times more is released at night by the brains pineal gland. "An oral dose of Melatonin resets the body's clock, causing sleepiness and fatigue in human subjects. "Other studies claim that Melatonin works as a "Super" antioxidant, helps to prevent jet-lag and aging, and improves sleep quality for shift workers and older patients. (Source - Reuters.)
Melatonin facilitates changing of endogenous circadian clock..."..Pilots and others, such as shift workers, whose work hours change on a regular basis, may benefit from Melatonin to help them to adjust to irregular schedules. "..in addition to it's chronobiotic effects, Melatonin is an effective hypnotic, especially when given to individuals attempting to sleep out-of-phase with their endogenous circadian pacemaker." (Source - Reuters Medical News)
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SOME OTHER CLAIMS WE HAVE SEEN FOR MELATONIN; Sleeping aid -
Life extender -
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Melatonin is sold as a health supplement. For legal reasons we make no claims for MELATONIN's medicinal use, and cannot substantiate any of the claims made on these pages, which have been reported by existing researchers and users. All information on these pages is included purely for your information and interest.